Noun

(en noun)

Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.

(often, in the plural) a change, especially in one's life or fortunes.

* 1667 , , Paradise Lost , vii, 351,

And God made.. the Stars, and set them in the firmament of Heaven to illuminate the Earth, and rule the day in their vicissitude ...

* 2003 , "US redeployments afoot in Asia", Christian Science Monitor , Nov. 18, Pg. 6.,

The vicissitudes of war in Iraq cast a dreary backdrop for Donald Rumsfeld's first visit to Asian military allies since he became US Defense Secretary in 2001.

* Seneca

Happy is the man who can endure the highest and lowest fortune. He who has endured such vicissitudes with equanimity has deprived misfortune of its power.

Noun

(en noun)

The act of innovating; the introduction of something new, in customs, rites, etc.

* {{quote-magazine, date=2013-06-21, author= Karen McVeigh

, volume=189, issue=2, page=10, magazine=(The Guardian Weekly) , title= US rules human genes can't be patented , passage=The US supreme court has ruled unanimously that natural human genes cannot be patented, a decision that scientists and civil rights campaigners said removed a major barrier to patient care and medical innovation .}}

*

A change effected by innovating; a change in customs;

Something new, and contrary to established customs, manners, or rites.

A newly formed shoot, or the annually produced addition to the stems of many mosses.