As nouns the difference between tweak and tween
is that
tweak is a sharp pinch or jerk; a twist or twitch while
tween is (animation) an action of
tweening (inserting frames for continuity); a sequence of frames generated by tweening or
tween can be a person who is neither a young child nor an adolescent, one of an age in the range of 8 to 12 years old or a similar range.
As verbs the difference between tweak and tween
is that
tweak is to pinch and pull with a sudden jerk and twist; to twitch while
tween is (cinematography) to generate intermediate frames in an animated sequence so as to give the appearance of smooth movement.