As a noun spite
is ill will or hatred toward another, accompanied with the disposition to irritate, annoy, or thwart; a desire to vex or injure; petty malice; grudge; rancor.
As a verb spite
is to treat maliciously; to try to injure or thwart.
As a preposition spite
is notwithstanding; despite.
As an adjective sadistic is
delighting in or feeling pleasure from the pain of others.