As nouns the difference between picture and guess
is that
picture is a representation of anything (as a person, a landscape, a building) upon canvas, paper, or other surface, by drawing, painting, printing, photography, etc while
guess is a prediction about the outcome of something, typically made without factual evidence or support.
As verbs the difference between picture and guess
is that
picture is to represent in or with a picture while
guess is to reach a partly (or totally) unqualified conclusion.