As nouns the difference between sim and sem

is that sim is any of the characters in the video game The Sims, which simulates aspects of a human social environment while sem is abbreviation of lang=en.

As an acronym SIM

is subscriber Identity Module.

As a proper noun Sim

is a male given name, diminutive of Simon and Simeon.

As an abbreviation Sem is

semitic.

As an initialism SEM is

scanning electron microscope.