Scorpio is a antonym of scorpius.

Scorpio is a alternative form of scorpius.

In astrology terms the difference between scorpius and scorpio

is that scorpius is : Scorpio while scorpio is : The zodiac sign for the scorpion, ruled by Mars and covering October 23 - November 21 (tropical astrology) or November 16 - December 15 (sidereal astrology).

As proper nouns the difference between scorpius and scorpio

is that scorpius is : A constellation of the zodiac, roughly shaped like a scorpion. Its brightest star is the red giant Antares while Scorpio is : Scorpius.

As a noun Scorpio is

someone with a Scorpio star sign.