Noun

(uncountable) The state or emotion of being sad.

(countable) An event in one's life that causes sadness.

She has experienced many sadnesses in her forty years.

Noun

(en noun)

The act of irritating, or exciting, or the state of being irritated; excitement; stimulation, usually of an undue and uncomfortable kind; especially, excitement of anger or passion; provocation; annoyance; anger.

* {{quote-magazine, year=2012, month=March-April

, author=Anna Lena Phillips , title=Sneaky Silk Moths , volume=100, issue=2, page=172 , magazine=(American Scientist) citation , passage=Last spring, the periodical cicadas emerged across eastern North America. Their vast numbers and short above-ground life spans inspired awe and irritation in humans—and made for good meals for birds and small mammals.}}

The act of exciting, or the condition of being excited to action, by stimulation; -- as, the condition of an organ of sense, when its nerve is affected by some external body; especially, the act of exciting muscle fibers to contraction, by artificial stimulation; as, the irritation of a motor nerve by electricity; also, the condition of a muscle and nerve, under such stimulation.

A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.