As nouns the difference between enchilada and quesadilla

is that enchilada is a Mexican dish made by wrapping a filling in a tortilla, then baking in a sauce while quesadilla is a Mexican dish made by filling a tortilla (corn or flour) with cheese, folding in half and toasting until the cheese is melted. Additional ingredients, such as meats (chicken or beef, commonly), or vegetables can be added. Often served with salsa, guacamole and/or sour cream.