As nouns the difference between substrate and bedrock

is that substrate is what an enzyme acts upon while bedrock is the solid rock that exists at some depth below the ground surface. Bedrock is rock "in place", as opposed to material that has been transported from another location by weathering and erosion.

As a verb substrate

is to strew or lay under.

As an adjective substrate

is having very slight furrows.

As a proper noun king

is the title of a king.

As a noun baron is

baron.

As a noun witness

is attestation of a fact or event; testimony.

As a verb witness

is to furnish proof of, to show.

As an adverb happily is

(archaic) by chance; perhaps.

As adjectives the difference between appropriate and justifiable

is that appropriate is set apart for a particular use or person; reserved while justifiable is that can be justified.

As a verb appropriate

is to make suitable; to suit.

As an adjective insane

is exhibiting unsoundness or disorder of mind; not sane; mad; deranged in mind; delirious; distracted .

As a noun big is

a biological insulation garment; an air-tight, full-body suit intended to prevent the spread of contaminants.

As nouns the difference between minimum and marginal

is that minimum is the lowest limit while marginal is something that is marginal.

As adjectives the difference between minimum and marginal

is that minimum is to the lowest degree while marginal is of, relating to, or located at or near a margin or edge; also figurative usages of location and margin (edge).

As nouns the difference between wants and preferences

is that wants is plural of lang=en while preferences is plural of lang=enCategory:English plurals.

As verbs the difference between wants and preferences

is that wants is third-person singular of want while preferences is third-person singular of preference.

As nouns the difference between help and endorsement

is that help is (uncountable) action given to provide assistance; aid while endorsement is the act or quality of endorsing.

As a verb help

is to provide assistance to (someone or something).

As adjectives the difference between widespread and substantial

is that widespread is affecting a large area (e.g. the entire land or body); broad in extent; widely diffused while substantial is having to substance; actually existing; real; as, substantial life.

As a noun substantial is

anything having substance; an essential part.

As an adjective obstinate

is stubbornly adhering to an opinion, purpose, or course, usually with implied unreasonableness; persistent.

As a noun truculence is

the state of being truculent.