Noun

(malignancies)

The state of being malignant or diseased.

A malignant cancer; specifically, any neoplasm that is invasive or otherwise not benign.

That which is malign; evil, depravity, malevolence.

* Shakespeare

The malignancy of my fate might perhaps distemper yours.

* {{quote-book, year=1902, author=Arthur Conan Doyle, title=The Hound of the Baskervilles citation

, passage=A cold wind swept down from it and set us shivering. Somewhere there, on that desolate plain, was lurking this fiendish man, hiding in a burrow like a wild beast, his heart full of malignancy against the whole race which had cast him out.}}

Noun

(en noun)

The bubonic plague, the pestilent disease caused by the virulent bacterium ''Yersinia pestis .

(pathology) An epidemic or pandemic caused by any pestilence, but specifically by the above disease.

A widespread affliction, calamity or destructive influx, especially when seen as divine retribution.

Ten Biblical plagues over Egypt, ranging from locusts to the death of the crown prince, finally forced Pharaoh to let Moses's people go.

A grave nuisance, whatever greatly irritates

Bart is an utter plague ; his pranks never cease.