As adverbs the difference between highest and supremely
is that highest is superlative of high POS=adverb while supremely is to the greatest, highest, or utmost degree.
As an adjective highest
is superlative of high.
highest
English
Adjective
(head)
(high)
Adverb
(head)
Anagrams
*
*
supremely
English
Adverb
(
en adverb)
To the greatest, highest, or utmost degree.
- They were supremely confident at the beginning of the season.