Heartache is a related term of despondency.
As nouns the difference between heartache and despondency
is that heartache is very sincere and difficult emotional problems or stress while despondency is the loss of hope or confidence; despair or dejection.
heartache
English
Alternative forms
* heart-ache
Noun
(
en noun)
Very sincere and difficult emotional problems or stress
despondency
English
Noun
(despondencies)
The loss of hope or confidence; despair or dejection.
A feeling of depression or disheartenment.