Depleter vs Deplete - What's the difference?

As a noun depleter

is any substance that causes depletion of something.

to empty or unload, as the vessels of the human system, by bloodletting or by medicine.

(en noun)

Any substance that causes depletion of something

*Normally used with a preceding noun e.g. ozone depleter English agent nouns

(deplet)

To empty or unload, as the vessels of the human system, by bloodletting or by medicine.

To reduce by destroying or consuming the vital powers of; to exhaust, as a country of its strength or resources, a treasury of money, etc.

* 2007 . Zerzan, John. Silence .

Its reserves have been invaded and depleted .