Defuse vs Deactivate - What's the difference?

As verbs the difference between defuse and deactivate

is that defuse is to remove the fuse from (a bomb, etc.) while deactivate is to make something inactive or no longer effective.

(Bomb disposal) (defus)

To remove the fuse from (a bomb, etc.).

To make less dangerous, tense, or hostile.

Compare (diffuse).

(defus)

(obsolete) To disorder; to make shapeless.

* 1605 , , I. iv. 2:

If but as well I other accents borrow / That can my speech defuse ,

* de-activate *

(deactivat)

(ergative) to make something inactive or no longer effective

to prevent the action of a biochemical agent (such as an enzyme)

to remove a person or piece of hardware from active military service