shame

As interjections the difference between shame and astaghfirullah

is that shame is a cry of admonition for the subject of a speech, often used reduplicated, especially in political debates while astaghfirullah is in the literal sense, "i seek forgiveness from allah"; a short prayer of redemption.

As a noun shame

is uncomfortable]] or painful feeling due to recognition or consciousness of impropriety, dishonor or other wrong in the opinion of the person experiencing the feeling it is caused by awareness of exposure of circumstances of [[unworthy|unworthiness or of improper or indecent conduct.

As a verb shame

is to feel shame, be ashamed.