As adjectives the difference between large and macro
is that
large is of considerable or relatively great size or extent while
macro is very large in scope or scale.
As nouns the difference between large and macro
is that
large is (music|obsolete) an old musical note, equal to two longas, four breves, or eight semibreves while
macro is (programming|computing) a comparatively human-friendly abbreviation of complicated input to a computer program or
macro can be (photography) macro lens.