As nouns the difference between monophysite and jacobite
is that monophysite
is a member of an early Christian sect which held that Jesus Christ has one nature, as opposed to the orthodox view that Christ has two natures, both fully man and fully God, and is co-eternal and co-substantial with the Father while Jacobite
is a supporter of the restoration of the Stuart kings to the thrones of England and Scotland in the late 17th century.
As an adjective Monophysite
is describing the beliefs of a Μonophysite.