Noun

(asperities)

Roughness as of stone or weather.

asperity of Maine's winter

Harshness, as of temper.

* 1878 : :

Go, ribald, get you hence
To your cabin with celerity.
This is the consequence
Of ill-advised asperity !

Something that is harsh and difficult to endure.

(geology) A part of a geological fault line that does not move.

Earthquakes begin and end at asperities .

Noun

(malignancies)

The state of being malignant or diseased.

A malignant cancer; specifically, any neoplasm that is invasive or otherwise not benign.

That which is malign; evil, depravity, malevolence.

* Shakespeare

The malignancy of my fate might perhaps distemper yours.

* {{quote-book, year=1902, author=Arthur Conan Doyle, title=The Hound of the Baskervilles citation

, passage=A cold wind swept down from it and set us shivering. Somewhere there, on that desolate plain, was lurking this fiendish man, hiding in a burrow like a wild beast, his heart full of malignancy against the whole race which had cast him out.}}