As adjectives the difference between amphiphilic and nonamphiphilic
is that amphiphilic
is (chemistry|of a molecule) being a detergent: having both hydrophilic and hydrophobic (or lipophilic) groups while nonamphiphilic
is not amphiphilic.
(chemistry, of a molecule) Being a detergent: having both hydrophilic and hydrophobic (or lipophilic) groups.
(biochemistry, of a protein, especially an alpha helix) Having one surface consisting of hydrophilic amino acids and the opposite surface consisting of hydrophobic (or lipophilic) ones.